Pathway Analysis

80
Total Pathways Analyzed
53
Druggable Pathways
66%
Surface Receptor Related
533
Unique Genes

Classification Results

42 Pathways
Upregulated (AGONIST targets)
38 Pathways
Downregulated (ANTAGONIST targets)
100%
Successfully classified by AI

Top Druggable Pathways

Immune Effector Process

NES: +2.45
18 genes
52 drug candidates
YES

Cell Surface Receptor Signaling

NES: +2.31
15 genes
38 drug candidates
YES

GPCR Signaling Pathway

NES: -2.18
12 genes
45 drug candidates
YES

Cytokine Mediated Signaling

NES: +2.09
14 genes
31 drug candidates
YES

Ion Channel Activity

NES: -1.95
11 genes
28 drug candidates
MAYBE

Analysis Method

Pathways are classified using a hybrid approach combining:

  • •Rule-based classification: Keyword matching against UniProt annotations for fast, deterministic results
  • •AI (Claude) classification: LLM analysis of pathway biology, surface receptor roles, and therapeutic potential
  • •Druggability assessment: Evaluation based on mechanism availability, safety profile, and clinical precedent